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Our Researchers

anderson lab, uc irvine

Dr. Aileen Anderson and Dr. Brian Cummings labs, summer 2015.

anderson lab, uc irvine

"NeuroNebulous," a neurosphere derived from human embryonic stem cells prior to testing in an animal model of traumatic brain injury.

anderson lab, uc irvine

A human neural stem cell derived "brain organoid" modeling of traumatic brain injury.

Aileen Anderson, PhD

Aileen Anderson is working to understand spinal cord injury and the role of inflammatory mechanisms in degeneration and regeneration in the injured central nervous system (CNS).

Her research involves the study of human CNS stem cell engraftment in the injured CNS and the mechanisms for the promotion of neurological recovery.

Brian Cummings, PhD

Brian Cummings is interested in neurotrauma and neuroregeneration, both at the cellular level and from a broader, behavioral perspective. He is also interested in ethics and informed consent for clinical trials.

His lab studies the interaction of human neural stem cells (hNSCs) in the normal, injured and aged CNS niches and the link between neurotrauma and subsequent development of AD-pathology and chronic traumatic encephalopathy (CTE). His lab is also screening neuroprotective drugs in a three-dimensional in vitro (cell culture dish) model of traumatic brain injury.

seiler lab, uc irvineMagdalene Seiler, PhD

The goal of Magdalene Seiler’s research is to develop retinal progenitor sheet transplants as a clinical treatment for retinal diseases such a retinitis pigmentosa and age-related macular degeneration, which affect both photoreceptors and retinal pigment epithelium (RPE).

The current focus of her research is to develop human embryonic stem cells (hESCs) into transplantable sheets of 3-D retina and RPE and to demonstrate vision restoration at the level of the superior colliculus and visual cortex in rat models of retinal degeneration.

She is also collaborating with Cummings to investigate whether human mesenchymal stem cells reverse retinal pathology and functional deficits resulting from repeated brain trauma.

David Reinkensmeyer, PhDreinkensmeyer lab, uc irvine

David Reinkensmeyer’s interests are in robotics and wearable sensors for neurorehabilitation, and in computational neuroscience for movement control. 

His research group designs technologies for movement rehabilitation after neurologic injury based on an understanding of neuromuscular plasticity mechanisms. Developing improved technology for rehabilitation movement training after neurologic injury not only helps people improve their movement recovery, but also enhances scientific understanding of use-dependent plasticity.

Such technology, along with computational models, will play an essential role in assessing and enhancing forthcoming neuro-repair therapies. 

Kelli Sharp, PT, DPT

kelli sharp uci

Pre-TEDX with my dancers, Anne Marie Lieby (UC Irvine_BIO/dance major) and Sonul Gupta (UCLA_BIO major).

kelli sharp uci

Sous Sous for Science lab group, summer of 2016.

Kelli Sharp’s research embodies two pillars.

The first pillar focuses on injury prevention and wellness for dancers using a motion-capture system and applying methods of analysis to determine the relationship of motion in space so we can further reduce injuries.

The second pillar focuses on the development of novel technologies to advance rehabilitation strategies for individuals with neurological disorders by incorporating tools, such as motion-capture systems and functional magnetic resonance (fMRI) with dance/movement therapy.

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